Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.63 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | RARB | P10826 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 6/20 | 0.58 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55063 | 1.00 | TP53 (0.65) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL9671377 | 0.98 | TP53 (0.62) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL9669601 | 0.94 | TP53 (0.56) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL5964408 | 0.87 | L3MBTL1 (0.56) | TP53TSHRNPC1LMNACYP1A2 | |
| SCHEMBL5867141 | 0.86 | TP53 (0.61) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL9670519 | 0.86 | TP53 (0.70) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL8081129 | 0.86 | TP53 (0.65) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL8081520 | 0.86 | TP53 (0.65) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL8081503 | 0.86 | TP53 (0.65) | TP53TSHRPLA2G4BNR5A1NPC1 | |
| SCHEMBL8072237 | 0.86 | TP53 (0.65) | TP53TSHRPLA2G4BNR5A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |