Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142239 | 0.86 | CDK2 (0.56) | TTRCYP1A2KMT2ABLMATIC | |
| SCHEMBL13410554 | 0.84 | MYC (0.50) | TTRCYP1A2MEN1KMT2ANSD2 | |
| Water SCHEMBL11321734 | 0.83 | TTR (0.46) | TTRCYP1A2MEN1KMT2ANSD2 | |
| SCHEMBL6242 | 0.75 | TTR (0.75) | TTRCYP1A2MEN1KMT2ANSD2 | |
| SCHEMBL29363198 | 0.75 | TTR (0.75) | TTRCYP1A2MEN1KMT2ANSD2 | |
| SCHEMBL30233642 | 0.75 | TTR (0.75) | TTRCYP1A2MEN1KMT2ANSD2 | |
| SCHEMBL9669736 | 0.75 | MYC (0.50) | CYP1A2KMT2ABLMRCE1ATIC | |
| SCHEMBL9670429 | 0.73 | TYMS (0.41) | CYP1A2MEN1KMT2AALDH1A1MYC | |
| Ammonia Solution, Strong SCHEMBL25312340 | 0.73 | TTR (0.72) | TTRCYP1A2MEN1KMT2ANSD2 | |
| Water SCHEMBL242080 | 0.73 | TTR (0.72) | TTRCYP1A2MEN1KMT2ANSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283959-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-02 | — | — | EP | disclosed |
| US-4912108-A | Containing hydroxy substitution | A/S FERROSAN (DK) | 1990-03-27 | — | — | US | disclosed |
| US-4889855-A | ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS | A/S FERROSAN (DK) | 1989-12-26 | — | — | US | disclosed |
| EP-0283959-A1 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-28 | — | — | EP | disclosed |