SCHEMBL5142239

SCHEMBL5142239

NS(=O)(=O)c1cccc2c1ccc1nc(O)c(O)nc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 1/20 0.56
CA2 P00918 6/20 0.49
CA1 P00915 5/20 0.49
CA9 Q16790 4/20 0.49
LDHA P00338 1/20 0.47
FTO Q9C0B1 1/20 0.44
HSD17B10 Q99714 2/20 0.42
CYP1A2 P05177 2/20 0.42
KDM4E B2RXH2 1/20 0.42
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
PKM P14618 1/20 0.42
HPGD P15428 1/20 0.42
BLM P54132 1/20 0.42
KMT2A Q03164 1/20 0.42
MYC P01106 1/20 0.41
MAX P61244 1/20 0.41
MAPK1 P28482 1/20 0.41
ATIC P31939 1/20 0.40
PNMT P11086 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9669736 0.86 MYC (0.50) CDK2CA2CA1CA9LDHA
SCHEMBL9670672 0.86 TTR (0.47) CDK2HSD17B10CYP1A2HPGDBLM
SCHEMBL9670649 0.81 HSD17B10 (0.48) CDK2CA2CA1CA9LDHA
SCHEMBL5886278 0.79 ALDH1A1 (0.54) CDK2CA2CA1CA9LDHA
Nbqx SCHEMBL29412437 0.76 MAPT (0.74) CDK2CA2CA1CA9HSD17B10
Nbqx SCHEMBL220464 0.76 MAPT (0.74) CDK2CA2CA1CA9HSD17B10
SCHEMBL9670429 0.76 TYMS (0.41) CYP1A2MAPTKMT2AMYCMAX
Nbqx SCHEMBL30728067 0.75 MAPT (0.73) CDK2CA2CA1CA9HSD17B10
Nbqx SCHEMBL26985644 0.75 MAPT (0.73) CDK2CA2CA1CA9HSD17B10
SCHEMBL9138970 0.74 CDK2 (0.78) CDK2CA2CA1CA9LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7101879-B2 Treatments for neurotoxicity in Alzheimer's Disease MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2006-09-05 US claimed
EP-1015013-A4 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES MASSACHUSETTS INST TECHNOLOGY (US) 2002-07-24 EP claimed
US-6172043-B1 GENETIC ENGINEERED POLYPEPTIDE MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-01-09 US claimed
EP-1015013-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-07-05 EP claimed
WO-1998030229-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1998-07-16 WO claimed
US-4889855-A ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS A/S FERROSAN (DK) 1989-12-26 US claimed
EP-1474126-A4 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE MASSACHUSETTS INST TECHNOLOGY (US) 2007-08-08 EP disclosed
US-7101879-B2 Treatments for neurotoxicity in Alzheimer's Disease MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2006-09-05 US disclosed
US-7067550-B2 Treatments for neurotoxicity in Alzheimer's Disease MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2006-06-27 US disclosed
EP-1341548-A4 METHODS FOR IDENTIFYING TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY $g(b)-AMYLOID PEPTIDES MASSACHUSETTS INST TECHNOLOGY (US) 2006-06-14 EP disclosed
US-6942963-B1 Methods for identifying treatments for neurotoxicity in Alzheimer's disease caused by β-amyloid peptides MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2005-09-13 US disclosed
EP-1474126-A2 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2004-11-10 EP disclosed
EP-1341548-A2 METHODS FOR IDENTIFYING TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY $g(b)-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2003-09-10 EP disclosed
US-6172043-B1 GENETIC ENGINEERED POLYPEPTIDE MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-01-09 US disclosed
EP-1015013-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-07-05 EP disclosed
WO-1998030229-A1 TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1998-07-16 WO disclosed
EP-0283959-B1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1992-01-02 EP disclosed
US-4912108-A Containing hydroxy substitution A/S FERROSAN (DK) 1990-03-27 US disclosed
US-4889855-A ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS A/S FERROSAN (DK) 1989-12-26 US disclosed
EP-0283959-A1 Heterocyclic compounds and their preparation and use NOVO NORDISK A/S (DK) 1988-09-28 EP disclosed