Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059320 | 0.84 | CREBBP (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5938069 | 0.76 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5938077 | 0.76 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5938063 | 0.76 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21966156 | 0.74 | CRBN (0.60) | CRBNDDB1 | |
| SCHEMBL19585834 | 0.74 | LMNA (0.48) | CRBNDDB1BCHEACHECTSL | |
| SCHEMBL10589424 | 0.74 | LMNA (0.48) | CRBNDDB1BCHEACHECTSL | |
| SCHEMBL11688745 | 0.72 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28532874 | 0.72 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28968894 | 0.72 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229566-B1 | 1-BENZENE SULFONYL 2-OXO-5-ALKOXY PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |
| US-4829079-A | AMNESIA | ROUSSEL UCLAF (FR) | 1989-05-09 | — | — | US | disclosed |
| EP-0229566-A2 | 1-Benzene sulfonyl 2-oxo-5-alkoxy pyrrolidines, process for their preparation, their use as medicine and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-07-22 | — | — | EP | disclosed |