Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670907 | 0.84 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9559115 | 0.82 | CREBBP (0.43) | CREBBPBRD4TSHRHTTLMNA | |
| SCHEMBL12821401 | 0.77 | GAA (0.44) | CREBBPBRD4PSEN1PSEN2APH1B | |
| SCHEMBL8809394 | 0.77 | CREBBP (0.54) | CREBBPBRD4HTTMAPTALDH1A1 | |
| SCHEMBL10702878 | 0.77 | BRD4 (0.47) | CREBBPBRD4CYP2C19ALDH1A1 | |
| SCHEMBL28968894 | 0.76 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28532874 | 0.76 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11688745 | 0.76 | LMNA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2173563 | 0.74 | PDE4A (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1929688 | 0.74 | CRBN (0.44) | CREBBPBRD4PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009114729-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL STORAGE DISEASES AND DISORDERS | IRM LLC (BM) | 2009-09-17 | — | — | WO | disclosed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| US-5705636-A | Cyclohexene derivatives | GLAXO WELLCOME S.P.A. (IT) | 1998-01-06 | — | — | US | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |
| EP-0617016-A1 | Cyclohexene derivatives | GLAXO S.p.A. (IT) | 1994-09-28 | — | — | EP | disclosed |