Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26695927 | 0.88 | CYP19A1 (0.38) | ALDH1A1CYP2D6GPR35VCAM1MAPK1 | |
| SCHEMBL30733364 | 0.88 | CYP19A1 (0.38) | ALDH1A1CYP2D6GPR35VCAM1MAPK1 | |
| SCHEMBL6074349 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6GPR35MAPTKDM4E | |
| SCHEMBL30210346 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6GPR35MAPTKDM4E | |
| SCHEMBL23198951 | 0.82 | GPR35 (0.55) | ALDH1A1CYP2D6GPR35MAPTKDM4E | |
| SCHEMBL9913609 | 0.81 | TSHR (0.51) | ALDH1A1GPR35VCAM1MAPTMEN1 | |
| SCHEMBL29953934 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GPR35VCAM1MAPTMAPK1 | |
| SCHEMBL27452392 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GPR35VCAM1MAPTMAPK1 | |
| SCHEMBL2815785 | 0.81 | MAPT (0.47) | ALDH1A1GPR35VCAM1MAPTKDM4E | |
| SCHEMBL22165198 | 0.81 | ALDH1A1 (0.41) | ALDH1A1CYP2D6GPR35VCAM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163551-B1 | PHENOTHIAZINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-08-12 | — | — | EP | disclosed |
| US-4705854-A | ANTIALLERGENS, ANTIHISTAMINES | BURROUGHS WELLCOME CO. (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0163551-A1 | Phenothiazine compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-12-04 | — | — | EP | disclosed |