Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672192 | 1.00 | NPSR1 (0.38) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL11452950 | 0.74 | NPSR1 (0.47) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL11445267 | 0.74 | NPSR1 (0.47) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL9672188 | 0.73 | NPSR1 (0.38) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL9667011 | 0.72 | NPSR1 (0.40) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL9667017 | 0.72 | NPSR1 (0.40) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL4753860 | 0.69 | NPSR1 (0.54) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL7912959 | 0.69 | NPSR1 (0.54) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL3190948 | 0.69 | NPSR1 (0.54) | NPSR1ALOX15HCAR2MAPT | |
| SCHEMBL11445592 | 0.69 | NPC1 (0.52) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254064-B1 | 2-(AMINOALKYLTHIO)METHYL-1,4-DIHYDROPYRIDINE, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-06-17 | — | — | EP | disclosed |
| US-5047414-A | Hypotensive agents | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-09-10 | — | — | US | disclosed |