Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADH1B | P00325 | 2/20 | 0.32 |
| ▸ | ADH1A | P07327 | 2/20 | 0.32 |
| ▸ | ADH7 | P40394 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667011 | 1.00 | NPSR1 (0.40) | NPSR1MAPTADH1BADH1AADH7 | |
| SCHEMBL9668403 | 0.85 | — | — | |
| SCHEMBL9668409 | 0.79 | — | — | |
| SCHEMBL9668309 | 0.75 | GAA (0.45) | MAPTADH1BADH1AADH7ADH1C | |
| SCHEMBL11452950 | 0.73 | NPSR1 (0.47) | NPSR1MAPTALOX15HCAR2 | |
| SCHEMBL11445267 | 0.73 | NPSR1 (0.47) | NPSR1MAPTALOX15HCAR2 | |
| SCHEMBL9672181 | 0.72 | NPSR1 (0.38) | NPSR1MAPTALOX15HCAR2 | |
| SCHEMBL9672192 | 0.72 | NPSR1 (0.38) | NPSR1MAPTALOX15HCAR2 | |
| SCHEMBL4753860 | 0.69 | NPSR1 (0.54) | NPSR1MAPTALOX15HCAR2 | |
| SCHEMBL3190948 | 0.69 | NPSR1 (0.54) | NPSR1MAPTALOX15HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312541-B1 | 2-(AMINOALKYLTHIO)METHYL-1,4-DIHYDROPYRIDINE, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-08-26 | — | — | EP | disclosed |
| EP-0254064-B1 | 2-(AMINOALKYLTHIO)METHYL-1,4-DIHYDROPYRIDINE, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-06-17 | — | — | EP | disclosed |
| US-5047414-A | Hypotensive agents | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0312541-A1 | 2-(AMINOALKYLTHIO)METHYL-1,4-DIHYDROPYRIDINE, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | BOEHRINGER BIOCHEMIA SRL (IT) | 1989-04-26 | — | — | EP | disclosed |
| EP-0254064-A1 | 2-(Aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-01-27 | — | — | EP | disclosed |
| WO-1988000187-A1 | 2-(AMINOALKYLTHIO)METHYL-1,4-DIHYDROPYRIDINE, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1988-01-14 | — | — | WO | disclosed |