SCHEMBL9673129

SCHEMBL9673129

COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN)C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 8/20 0.80
CYP1A2 P05177 7/20 0.80
MAPT P10636 7/20 0.80
CACNA1C Q13936 6/20 0.80
CYP3A4 P08684 6/20 0.80
CYP2C9 P11712 6/20 0.80
CYP2C19 P33261 6/20 0.80
KMT2A Q03164 5/20 0.80
LMNA P02545 4/20 0.80
OPRM1 P35372 4/20 0.80
KCNH2 Q12809 4/20 0.80
TSHR P16473 4/20 0.80
NFKB1 P19838 4/20 0.80
HIF1A Q16665 4/20 0.80
ABCB11 O95342 3/20 0.80
HTR2B P41595 3/20 0.80
SCN5A Q14524 3/20 0.80
CYP2D6 P10635 3/20 0.80
DRD1 P21728 3/20 0.80
ABCC4 O15439 2/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7486022 0.96 CACNA1D (0.72) ADORA3CYP1A2MAPTCACNA1CCYP3A4
Hydrochloric Acid SCHEMBL7486013 0.94 CACNA1D (0.70) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL9672835 0.94 ADORA3 (0.77) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL9673716 0.93 CACNA1C (0.76) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL11824944 0.92 CYP1A2 (0.82) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL9674077 0.92 CACNA1C (0.74) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL7158381 0.91 ADORA3 (0.80) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL9175041 0.91 ADORA3 (0.80) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL7282364 0.90 CYP1A2 (0.79) ADORA3CYP1A2MAPTCACNA1CCYP3A4
SCHEMBL5085498 0.90 ADORA3 (0.86) ADORA3CYP1A2MAPTCACNA1CCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0250725-B1 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM HEUMANN PHARMA GMBH & CO (DE) 1992-11-04 EP disclosed
US-4757080-A Pharmaceuticals HEUMANN PHARMA GMBH & CO. (DE) 1988-07-12 US disclosed
EP-0250725-A1 1,4-Dihydropyridine derivatives, processes for their preparation and medicaments containing them HEUMANN PHARMA GMBH & CO (DE) 1988-01-07 EP disclosed