Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733251 | 0.81 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL2734248 | 0.81 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL13164002 | 0.81 | KEAP1 (0.57) | KEAP1NFE2L2HDAC1HDAC2HDAC3 | |
| SCHEMBL2734662 | 0.81 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| O-Xylene SCHEMBL27631146 | 0.80 | ALDH1A1 (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL9099317 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTEPHX2 | |
| SCHEMBL9101224 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTEPHX2 | |
| SCHEMBL8778823 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTEPHX2 | |
| SCHEMBL9102994 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTEPHX2 | |
| SCHEMBL8778811 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312040-B1 | 2,4-DISUBSTITUTED DERIVATIVES OF TETRAHYDROFURAN | J. URIACH & CIA. S.A. (ES) | 1992-06-03 | — | — | EP | disclosed |
| US-4997843-A | Platelet activating factor, anticoagulants | J URIACH & CIA S.A. (ES) | 1991-03-05 | — | — | US | disclosed |
| EP-0312040-A2 | 2,4-Disubstituted derivatives of tetrahydrofuran | J. URIACH & CIA. S.A. (ES) | 1989-04-19 | — | — | EP | disclosed |