Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731740 | 0.90 | PPARA (0.53) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL22836927 | 0.88 | AKR1C3 (0.63) | AKR1C3AKR1C2KDM4EALDH1A1HPGD | |
| SCHEMBL27711218 | 0.87 | MAOB (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL27731790 | 0.85 | CISD1 (0.42) | KDM4EALDH1A1MAPTSMN1; SMN2ASPH | |
| SCHEMBL27711246 | 0.84 | SMN1; SMN2 (0.44) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9741286 | 0.84 | NPC1 (0.53) | KDM4EALDH1A1HPGDASPHRIOX2 | |
| SCHEMBL27731819 | 0.83 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTLMNAHPGD | |
| SCHEMBL27711221 | 0.82 | MEN1 (0.51) | AKR1C3AKR1C2KDM4EALDH1A1MAPT | |
| SCHEMBL27731821 | 0.82 | MEN1 (0.54) | KDM4EALDH1A1MAPTSMN1; SMN2ASPH | |
| SCHEMBL27711447 | 0.82 | GAA (0.50) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517877-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-12-16 | — | — | EP | disclosed |
| WO-1992012137-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1992-07-23 | — | — | WO | disclosed |