Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719936 | 0.90 | GAA (0.65) | ALDH1A1MAPTGAATHRBATM | |
| SCHEMBL6215242 | 0.90 | ALDH1A1 (0.71) | ALDH1A1HTTKDM4EPOLB | |
| SCHEMBL1720494 | 0.89 | MAPT (0.72) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL21411461 | 0.88 | ALDH1A1 (0.62) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL3787646 | 0.88 | ALDH1A1 (0.59) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL8179660 | 0.88 | ALDH1A1 (0.59) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL8263558 | 0.88 | ALDH1A1 (0.59) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL9214032 | 0.86 | GAA (0.62) | ALDH1A1MAPTGAATHRBATM | |
| SCHEMBL10568513 | 0.85 | GAA (0.49) | ALDH1A1MAPTGAACYP3A4CYP2D6 | |
| SCHEMBL3055942 | 0.84 | GAA (0.60) | ALDH1A1MAPTGAACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275092-B1 | PROCESS FOR PREPARING (+)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1,7-DICARBOXYLATES | SYNTEX (U.S.A.) INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| US-4874872-A | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-17 | — | — | US | disclosed |
| US-4849526-A | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0275092-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1988-07-20 | — | — | EP | disclosed |