Sugi Predict

Sugi Predict / Compounds / SCHEMBL3787646

SCHEMBL3787646

SCHEMBL3787646

CCOC(=O)C1CCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.59
▸ KMT2A Q03164 3/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ TSHR P16473 1/20 0.59
▸ HPGD P15428 1/20 0.55
▸ MAPT P10636 3/20 0.54
▸ RECQL P46063 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ CYP3A4 P08684 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ CYP2C9 P11712 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ HTT P42858 2/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ EPHX1 P07099 1/20 0.46
▸ PTPN2 P17706 1/20 0.45
▸ PTPN1 P18031 1/20 0.45
▸ PTPN6 P29350 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8263558 1.00 ALDH1A1 (0.59) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL8179660 1.00 ALDH1A1 (0.59) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL792692 0.92 ALDH1A1 (0.61) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL550224 0.92 ALDH1A1 (0.61) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL3321644 0.92 ALDH1A1 (0.61) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL337418 0.91 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL30987134 0.91 ALDH1A1 (0.50) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL18391124 0.90 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL30987074 0.90 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1TSHRHPGD
SCHEMBL1441478 0.90 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024220399-A1 PYRAZOLOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2024-10-24 — — WO disclosed
WO-2024151112-A1 PYRAZOLOPYRIMIDINE DERIVATIVE AS CYCLIN-DEPENDENT KINASE 9 INHIBITOR 주식회사 티움바이오 2024-07-18 — — WO disclosed
WO-2024151112-A1 PYRAZOLOPYRIMIDINE DERIVATIVE AS CYCLIN-DEPENDENT KINASE 9 INHIBITOR 주식회사 티움바이오 2024-07-18 — — WO disclosed
US-11993595-B2 Compounds MISSION THERAPEUTICS LIMITED (GB) 2024-05-28 — — US disclosed
US-11958861-B2 Spirocyclic lactams as JAK2 V617F inhibitors INCYTE CORPORATION (US) 2024-04-16 — — US disclosed
EP-3774805-B1 HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER SERVIER LAB (FR) 2024-01-10 — — EP disclosed
EP-4298099-A1 SPIROCYCLIC LACTAMS AS JAK2 V617F INHIBITORS Incyte Corporation (US) 2024-01-03 — — EP disclosed
CN-111936499-B Heterobicyclic inhibitors of MAT2A and methods for treating cancer 法国施维雅药厂 2023-09-19 — — CN disclosed
CN-111592534-B New compounds 特殊治疗有限公司 2023-06-30 — — CN disclosed
US-20230192696-A1 SPIRO COMPOUNDS AS INHIBITORS OF KRAS INCYTE CORPORATION 2023-06-22 — — US disclosed
US-20090324581-A1 HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE DAIICHI SANKYO COMPANY LIMITED (JP) 2009-12-31 — — US disclosed
US-20090118284-A1 Novel compounds that are ERK inhibitors MERCK SHARP & DOHME LLC 2009-05-07 — — US disclosed
EP-2017263-A1 HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-01-21 — — EP disclosed
US-20070232610-A1 Novel compounds that are ERK inhibitors SCHERING CORPORATION 2007-10-04 — — US disclosed
US-20070191604-A1 Novel compounds that are ERK inhibitors SCHERING CORPORATION 2007-08-16 — — US disclosed
US-20070191333-A1 Antibacterial agents WARNER LAMBERT COMPANY LLC 2007-08-16 — — US disclosed
US-20070191333-A1 Antibacterial agents WARNER LAMBERT COMPANY LLC 2007-08-16 — — US disclosed
EP-1687296-A1 ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES Warner-Lambert Company LLC (US) 2006-08-09 — — EP disclosed
WO-2005049602-A1 QUINOLONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2005-06-02 — — WO disclosed
WO-2005049605-A1 ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES WARNER-LAMBERT COMPANY LLC (US) 2005-06-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11958861-B2 Spirocyclic lactams as JAK2 V617F inhibitors JAK2, JAK1, STAT5A ALDH1A1 3023/4885KMT2A 700/4885MEN1 2058/4885
US-20090118284-A1 Novel compounds that are ERK inhibitors MAPK1, MAPK4, MAPK10 ALDH1A1 277/4885KMT2A 1891/4885MEN1 2093/4885
US-20070191333-A1 Antibacterial agents MRPL21, RPN2, FBL ALDH1A1 637/4885KMT2A 4819/4885MEN1 2732/4885
US-20070191604-A1 Novel compounds that are ERK inhibitors MAPK1, MAPK4, MAPKAPK2 ALDH1A1 342/4885KMT2A 1822/4885MEN1 1940/4885
US-11993595-B2 Compounds UCHL1, UCHL3, UCHL5 ALDH1A1 300/4885KMT2A 280/4885MEN1 1789/4885
US-20070232610-A1 Novel compounds that are ERK inhibitors MAPK1, MAPK4, MAPKAPK2 ALDH1A1 342/4885KMT2A 1822/4885MEN1 1940/4885
US-20090324581-A1 HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE S1PR3, S1PR2, S1PR1 ALDH1A1 1730/4885KMT2A 840/4885MEN1 1522/4885
US-20230192696-A1 SPIRO COMPOUNDS AS INHIBITORS OF KRAS KRAS, HRAS, NRAS ALDH1A1 799/4885KMT2A 4025/4885MEN1 971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.