SCHEMBL9675425

SCHEMBL9675425

O=C1Nc2ccccc2N(C(=O)N2CCCC(CCN3CCCCCC3)C2)c2ncccc21

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.47
CHRM1 P11229 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9673861 1.00 CHRM2 (0.47) CHRM2CHRM1
SCHEMBL9675917 0.97 CHRM2 (0.49) CHRM2CHRM1
SCHEMBL9676036 0.96 CHRM2 (0.48) CHRM2CHRM1
SCHEMBL9674158 0.95 CHRM2 (0.47) CHRM2CHRM1
SCHEMBL9674043 0.95
SCHEMBL9678379 0.94
SCHEMBL9674009 0.94 CHRM2 (0.48) CHRM2
SCHEMBL9673959 0.93 CHRM2 (0.54) CHRM2CHRM1
Hydrochloric Acid SCHEMBL9673831 0.93 LMNA (0.54) CHRM2CHRM1
Hydrochloric Acid SCHEMBL9675612 0.92 LMNA (0.55) CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306698-B1 CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THESE COMPOUNDS Dr. Karl Thomae GmbH (DE) 1992-03-25 EP disclosed
US-4931436-A BRADYCARDIAL AGENTS DR. KARL THOMAE GMBH (DE) 1990-06-05 US disclosed
EP-0306698-A1 Condensed diazepinones, processes for their preparation, and medicaments containing these compounds Dr. Karl Thomae GmbH (DE) 1989-03-15 EP disclosed