SCHEMBL9677192

SCHEMBL9677192

O=C1OC(CN2CCC(c3ccccc3)CC2)CN1c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 13/20 0.56
SIGMAR1 Q99720 6/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9679006 0.92 SIGMAR1 (0.53) GRM2SIGMAR1
SCHEMBL9677377 0.89 SIGMAR1 (0.71) GRM2SIGMAR1
SCHEMBL9844365 0.88 HTR7 (0.58) GRM2SIGMAR1
SCHEMBL7299801 0.85 SIGMAR1 (0.78) GRM2SIGMAR1
SCHEMBL9678366 0.82 GRM2 (0.67) GRM2SIGMAR1
SCHEMBL9677080 0.81 MEN1 (0.52) GRM2SIGMAR1
SCHEMBL5527597 0.80 CYP2D6 (0.52)
SCHEMBL7481896 0.79 GRM2 (0.58) GRM2SIGMAR1
SCHEMBL9678722 0.78 SIGMAR1 (0.72) GRM2SIGMAR1
SCHEMBL15757963 0.78 HTR2B (0.69) GRM2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0300272-B1 OXAZOLIDINONES MERCK PATENT GmbH (DE) 1992-09-16 EP disclosed
US-4970217-A NEUROLEPTIC MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1990-11-13 US disclosed
EP-0300272-A1 Oxazolidinones MERCK PATENT GmbH (DE) 1989-01-25 EP disclosed