Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676280 | 0.89 | SIGMAR1 (0.41) | ACHEGRK6SIGMAR1ROCK1CA2 | |
| SCHEMBL2103952 | 0.79 | FLT3 (0.50) | ACHEFLT3CA2F2F10 | |
| SCHEMBL12708370 | 0.77 | ACHE (0.41) | ACHEFLT3CA2F2F10 | |
| SCHEMBL9676534 | 0.76 | GRK6 (0.67) | ACHEGRK6SIGMAR1ROCK1SMN1; SMN2 | |
| SCHEMBL9678236 | 0.76 | CDC25C (0.51) | ACHESIGMAR1CA2MEN1ALDH1A1 | |
| SCHEMBL9677439 | 0.74 | KCNH2 (0.50) | ACHESMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL12394347 | 0.74 | PRKCI (0.47) | ACHEFLT3CA2F2F10 | |
| SCHEMBL9675507 | 0.73 | SIGMAR1 (0.41) | ACHEGRK6SIGMAR1ROCK1CA2 | |
| SCHEMBL9627913 | 0.72 | SIGMAR1 (0.66) | SIGMAR1CYP1A2CYP3A4CYP2D6GFER | |
| SCHEMBL8179634 | 0.71 | TLR8 (0.47) | ACHEGRK6FLT3CA2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | claimed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | claimed |
| US-5158964-A | Benzoxazole sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055473-A | QUINOLINYL SULFONAMIDE ANTI-ARRHYTHMIC AGENTS AND USE THEREAS | PFIZER INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4956382-A | TERTIARY AMINE HETEROCYCLIC SULFONAMIDES | PFIZER INC. (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | disclosed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | disclosed |