SCHEMBL9679271

SCHEMBL9679271

O=C(Cl)c1ccc(/C=C\c2ccc(C(=O)Cl)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.48
ALDH1A1 P00352 3/20 0.46
PRMT5 O14744 1/20 0.46
PRMT1 Q99873 1/20 0.46
HPGD P15428 1/20 0.46
CYP2C19 P33261 1/20 0.46
HSD17B10 Q99714 1/20 0.46
KDM1A O60341 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
F3 P13726 2/20 0.45
MAPT P10636 1/20 0.43
TNFRSF1A P19438 1/20 0.43
CYP1A2 P05177 1/20 0.43
MAOB P27338 3/20 0.42
CXCL12 P48061 1/20 0.42
MAOA P21397 1/20 0.41
SNCA P37840 1/20 0.41
FBP1 P09467 1/20 0.41
PTPN1 P18031 1/20 0.40
CYP1B1 Q16678 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL994964 1.00 HDAC1 (0.48) HDAC1ALDH1A1PRMT5PRMT1HPGD
SCHEMBL994963 1.00 HDAC1 (0.48) HDAC1ALDH1A1PRMT5PRMT1HPGD
Hydrochloric Acid SCHEMBL7751049 0.97 HDAC1 (0.47) HDAC1ALDH1A1PRMT5PRMT1HPGD
SCHEMBL10704031 0.91 ALDH1A1 (0.56) HDAC1ALDH1A1PRMT5PRMT1HPGD
SCHEMBL10460408 0.91 HDAC1 (0.62) HDAC1ALDH1A1HDAC6F3MAPT
SCHEMBL10460407 0.91 HDAC1 (0.62) HDAC1ALDH1A1HDAC6F3MAPT
SCHEMBL10704028 0.91 ALDH1A1 (0.56) HDAC1ALDH1A1PRMT5PRMT1HPGD
SCHEMBL14984235 0.89 MAPT (0.60) HDAC1ALDH1A1HPGDHDAC6MAPT
SCHEMBL5692757 0.89 HDAC1 (0.46) HDAC1ALDH1A1PRMT5PRMT1HPGD
SCHEMBL25202703 0.87 HDAC1 (0.65) HDAC1ALDH1A1HPGDCYP2C19KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5136013-A Polyesters BAYER AKTIENGESELLSCHAFT (DE) 1992-08-04 US disclosed
US-5068300-A BIFUNCTIONAL STILBENE COMPOUNDS CONTAINING AT LEAST ONE Z-CONFIGURATED STILBENE GROUP, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF POLYMERS BAYER AKTIENGESELLSCHAFT (DE) 1991-11-26 US disclosed