Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | SORD | Q00796 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10843856 | 0.91 | KDM4E (0.50) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL10848984 | 0.84 | KDM4E (0.57) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL7777530 | 0.83 | KDM4E (0.56) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL9722202 | 0.81 | DRD2 (0.59) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL6884485 | 0.79 | KDM4E (0.65) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL5090039 | 0.79 | KDM4E (0.54) | KDM4EMAPTHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8401502 | 0.78 | KDM4E (0.68) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL4558892 | 0.77 | KDM4E (0.71) | KDM4EMAPTHTR1ADRD2HTR2A | |
| SCHEMBL9381820 | 0.77 | HTR1A (0.48) | HTR1ADRD2HTR2A | |
| SCHEMBL11637734 | 0.76 | KDM4E (0.65) | KDM4EMAPTHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590196-A | NON-OPIATE | BRISTOL-MYERS COMPANY (US) | 1986-05-20 | — | — | US | claimed |
| US-5173490-A | Antipsychotic drugs having no side effects; anxiolytic agents; analgesics; tranquilizers; sedatives; antidepressants | ADIR ET COMPAGNIE (FR) | 1992-12-22 | — | — | US | disclosed |
| EP-0494817-A1 | Benzisoxazole and benzisothiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-07-15 | — | — | EP | disclosed |