Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.50 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680982 | 1.00 | KMT2A (0.50) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL21065589 | 0.85 | KMT2A (0.51) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL3123681 | 0.84 | MAPT (0.50) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL3123693 | 0.84 | MAPT (0.50) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL6220713 | 0.84 | MAPT (0.50) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL6220710 | 0.84 | MAPT (0.50) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL9681733 | 0.83 | MAPT (0.49) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL9681724 | 0.83 | MAPT (0.49) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL6219624 | 0.83 | LMNA (0.49) | KMT2AMAPTMEN1LMNAPLIN1 | |
| SCHEMBL7882435 | 0.83 | MAPT (0.49) | KMT2AMAPTMEN1LMNAPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| US-5091395-A | Hypotensive agents | GLAXO S.P.A. (IT) | 1992-02-25 | — | — | US | disclosed |
| EP-0226271-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| EP-0226271-A1 | 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation | GLAXO S.p.A. (IT) | 1987-06-24 | — | — | EP | disclosed |