Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.49 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681724 | 1.00 | MAPT (0.49) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL9680642 | 0.88 | MAPT (0.47) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL4388708 | 0.83 | CYP1A2 (0.51) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL9680987 | 0.83 | KMT2A (0.50) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL9680982 | 0.83 | KMT2A (0.50) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL24611347 | 0.82 | LMNA (0.57) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL9681557 | 0.82 | MEN1 (0.38) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL28330434 | 0.82 | LMNA (0.57) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL9681561 | 0.82 | MEN1 (0.38) | MAPTMEN1KMT2ALMNAPLIN1 | |
| SCHEMBL14198607 | 0.79 | MEN1 (0.72) | MAPTMEN1KMT2ALMNAPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| US-5091395-A | Hypotensive agents | GLAXO S.P.A. (IT) | 1992-02-25 | — | — | US | disclosed |
| EP-0226271-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| EP-0226271-A1 | 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation | GLAXO S.p.A. (IT) | 1987-06-24 | — | — | EP | disclosed |