Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968177 | 0.86 | KDM1A (0.47) | KDM1ABRD4MAP1LC3BHTR2CHTR2B | |
| SCHEMBL21336326 | 0.77 | CASP1 (0.33) | ALDH1A1CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL30217494 | 0.77 | KDM1A (0.41) | KDM1AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL10336974 | 0.77 | RAB9A (0.41) | HTR2CHTR2BHTR2AALDH1A1CYP3A4 | |
| SCHEMBL31053095 | 0.77 | HTR2C (0.52) | KDM1AHTR2CHTR2BSLC6A2HTR2A | |
| SCHEMBL5406701 | 0.77 | DPP4 (0.49) | HTR2CHTR2BHTR2ASMN1; SMN2 | |
| SCHEMBL29557462 | 0.77 | HTR2C (0.52) | KDM1AHTR2CHTR2BSLC6A2HTR2A | |
| SCHEMBL10046437 | 0.77 | KDM1A (0.50) | KDM1ABRD4MAP1LC3BHTR2CHTR2B | |
| SCHEMBL29427088 | 0.77 | KDM1A (0.50) | KDM1ABRD4MAP1LC3BHTR2CHTR2B | |
| SCHEMBL10740295 | 0.73 | LMNA (0.40) | ALDH1A1LMNAHTTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | BACE1, BACE2, APP | KDM1A 1158/4885BRD4 560/4885MAP1LC3B 264/4885 |
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | KDM1A 1158/4885BRD4 560/4885MAP1LC3B 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.