Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 5/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1152811 | 0.82 | MAPT (0.48) | IDO1MAPTLMNAHPGDKMT2A | |
| SCHEMBL916442 | 0.79 | IDO1 (0.52) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL11120217 | 0.79 | IDO1 (0.52) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL917110 | 0.79 | CDC25B (0.46) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL9856931 | 0.79 | CDC25B (0.46) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL917397 | 0.77 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL12589641 | 0.77 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL1542662 | 0.77 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL917772 | 0.77 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3ANSD2 | |
| SCHEMBL11057934 | 0.74 | IDO1 (0.40) | IDO1DNMT1DNMT3LDNMT3ANSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175319-A | Antiprotozoa agent, useful for treating malaria, theileriosis, coccidiosis and prophylaxix | BURROUGHS WELLCOME CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5053432-A | Antiprotozoa agents; treatment of malaria | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123238-B1 | NAPHTHOQUINONE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-06-10 | — | — | EP | disclosed |
| EP-0123238-A2 | Naphthoquinone derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |