Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.52 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | PTPRC | P08575 | 2/20 | 0.51 |
| ▸ | CDC25B | P30305 | 2/20 | 0.51 |
| ▸ | PTPRF | P10586 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | APAF1 | O14727 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | TDP2 | O95551 | 4/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120217 | 1.00 | IDO1 (0.52) | IDO1DNMT1DNMT3LDNMT3APTPN1 | |
| SCHEMBL917397 | 0.80 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3AMAPT | |
| SCHEMBL917772 | 0.80 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3AMAPT | |
| SCHEMBL12589641 | 0.80 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3AMAPT | |
| SCHEMBL1542662 | 0.80 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3AMAPT | |
| SCHEMBL917110 | 0.79 | CDC25B (0.46) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL9682118 | 0.79 | IDO1 (0.44) | IDO1DNMT1DNMT3LDNMT3APTPN1 | |
| SCHEMBL9856931 | 0.79 | CDC25B (0.46) | IDO1DNMT1DNMT3LDNMT3ACDC25B | |
| SCHEMBL16363681 | 0.79 | MAPT (0.57) | PTPN1PTPRCCDC25BPTPRFMAPT | |
| Parvaquone SCHEMBL916441 | 0.79 | APAF1 (0.52) | PTPN1PTPRCCDC25BPTPRFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283499-B2 | Preparation of naphthoquinone compounds using 2,3-dihalonaphthoquinone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-09 | — | — | US | claimed |
| US-20110004024-A1 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2,3-DIHALONAPHTHOQUINONE | ALKEM LABORATORIES LIMITED (IN) | 2011-01-06 | — | — | US | claimed |
| EP-2250145-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | Alkem Laboratories Ltd. (IN) | 2010-11-17 | — | — | EP | claimed |
| WO-2009122432-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | ALKEM LABORATORIES LTD. (IN) | 2009-10-08 | — | — | WO | claimed |
| US-8283499-B2 | Preparation of naphthoquinone compounds using 2,3-dihalonaphthoquinone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-09 | — | — | US | disclosed |
| US-8283499-B2 | Preparation of naphthoquinone compounds using 2,3-dihalonaphthoquinone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-09 | — | — | US | disclosed |
| US-8283499-B2 | Preparation of naphthoquinone compounds using 2,3-dihalonaphthoquinone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-09 | — | — | US | disclosed |
| US-20110004024-A1 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2,3-DIHALONAPHTHOQUINONE | ALKEM LABORATORIES LIMITED (IN) | 2011-01-06 | — | — | US | disclosed |
| US-20110004024-A1 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2,3-DIHALONAPHTHOQUINONE | ALKEM LABORATORIES LIMITED (IN) | 2011-01-06 | — | — | US | disclosed |
| US-20110004024-A1 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2,3-DIHALONAPHTHOQUINONE | ALKEM LABORATORIES LIMITED (IN) | 2011-01-06 | — | — | US | disclosed |
| EP-2250145-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | Alkem Laboratories Ltd. (IN) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009122432-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | ALKEM LABORATORIES LTD. (IN) | 2009-10-08 | — | — | WO | disclosed |
| WO-2009122432-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | ALKEM LABORATORIES LTD. (IN) | 2009-10-08 | — | — | WO | disclosed |
| US-4507241-A | Method for the hydrocarbylation of naphthoquinone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004024-A1 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2,3-DIHALONAPHTHOQUINONE | RECQL, NQO2, NQO1 | IDO1 1737/4885DNMT1 1735/4885DNMT3L 2599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.