Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NSD2 | O96028 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917110 | 1.00 | CDC25B (0.46) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL11028173 | 0.86 | MAPT (0.42) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL1542903 | 0.82 | CDC25B (0.56) | CDC25BMAPTLMNAMEN1KMT2A | |
| SCHEMBL917366 | 0.82 | CDC25B (0.56) | CDC25BMAPTLMNAMEN1KMT2A | |
| SCHEMBL1151720 | 0.82 | CDC25B (0.56) | CDC25BMAPTLMNAMEN1KMT2A | |
| SCHEMBL916442 | 0.79 | IDO1 (0.52) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL11120217 | 0.79 | IDO1 (0.52) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL9682118 | 0.79 | IDO1 (0.44) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL11057934 | 0.77 | IDO1 (0.40) | IDO1DNMT1DNMT3LDNMT3AMAPT | |
| SCHEMBL1542662 | 0.77 | KMT2A (0.68) | IDO1DNMT1DNMT3LDNMT3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122432-A2 | PREPARATION OF NAPHTHOQUINONE COMPOUNDS USING 2, 3-DIHALONAPTHOQUINONE | ALKEM LABORATORIES LTD. (IN) | 2009-10-08 | — | — | WO | disclosed |
| US-5053418-A | Synergistic mixture of 2-(4,-(4-chlorophenyl)cyclohexyl)3-hydr oxy-1,4 napthoquinone and 3,5-dichloro-2,6 dichloropyridinol | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123239-B1 | IMPROVEMENTS IN OR RELATING TO ANTIPROTOZOAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0077551-B1 | 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL AND VETERINARY FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-06-12 | — | — | EP | disclosed |
| EP-0123239-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |
| EP-0077551-A2 | 1.4-Naphthoquinones, methods for their preparation, pharmaceutical and veterinary formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-27 | — | — | EP | disclosed |