Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.68 |
| ▸ | PGR | P06401 | 2/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682264 | 1.00 | LMNA (0.68) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL27276045 | 0.99 | LMNA (0.70) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9680608 | 0.91 | ADORA3 (0.58) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL9680600 | 0.90 | ADORA3 (0.57) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL9680603 | 0.90 | ADORA3 (0.57) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9873166 | 0.88 | LMNA (0.51) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9873154 | 0.88 | LMNA (0.51) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9874319 | 0.86 | NR1I2 (0.52) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9874306 | 0.86 | NR1I2 (0.52) | LMNACYP2C9ADORA3CYP3A4CYP2C19 | |
| SCHEMBL9872301 | 0.86 | CYP2C9 (0.81) | LMNACYP2C9ADORA3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| CN-1017893-B | PROCESS FOR THE PREPARATION OF HETEROCYCLIC DERIVATIVES | GLAXO SPA (IT) | 1992-08-19 | — | — | CN | disclosed |
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |
| CN-85107087-A | The preparation technology of Hete rocyclic derivatives | — | 1986-12-31 | — | — | CN | disclosed |