Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 11/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682885 | 1.00 | ADRB3 (0.65) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9684040 | 0.83 | ADRB3 (0.87) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9685312 | 0.83 | ADRB3 (0.87) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9684048 | 0.83 | ADRB3 (0.87) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9787241 | 0.82 | MEN1 (0.64) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9787233 | 0.82 | MEN1 (0.64) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL10873682 | 0.82 | ADRB3 (0.68) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL10873694 | 0.82 | ADRB3 (0.68) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL10873688 | 0.82 | ADRB3 (0.68) | ADRB3ADRB1ADRB2MEN1ALDH1A1 | |
| SCHEMBL9684291 | 0.82 | ADRB3 (0.61) | ADRB3ADRB1ADRB2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | claimed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |