Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681394 | 0.92 | MAPT (0.74) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL13186987 | 0.90 | MAPT (0.61) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL10509856 | 0.87 | MEN1 (0.54) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL2130528 | 0.87 | MAPT (0.60) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL30984081 | 0.86 | MAPT (0.57) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL25968280 | 0.86 | MAPT (0.57) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL30983902 | 0.86 | MAPT (0.62) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL14356251 | 0.86 | MAPT (0.53) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL9683242 | 0.85 | MAPT (0.84) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL9683146 | 0.82 | MAPT (0.57) | MAPTL3MBTL1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |