Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 4/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474847 | 0.89 | HTR6 (0.58) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL10509856 | 0.87 | MEN1 (0.54) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL9682949 | 0.87 | MAPT (0.67) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL30984081 | 0.86 | MAPT (0.57) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL25968280 | 0.86 | MAPT (0.57) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL14356251 | 0.86 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL5579572 | 0.85 | MAPT (0.56) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL17934213 | 0.85 | SMN1; SMN2 (0.62) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL7318993 | 0.83 | MAPT (0.68) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL1180504 | 0.83 | MAPT (0.57) | MAPTRAB9ASMN1; SMN2NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-A1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | Pfizer Inc. (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146488-A1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER INC. (US) | 2010-12-23 | — | — | WO | disclosed |
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |