Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518353 | 0.91 | MEN1 (0.53) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL9683006 | 0.88 | PSEN1 (0.43) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL9682947 | 0.86 | POLB (0.52) | ALDH1A1NPSR1MAPK1MAPTMEN1 | |
| SCHEMBL6816481 | 0.83 | ALDH1A1 (0.58) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL30610948 | 0.83 | ALDH1A1 (0.58) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL30641694 | 0.80 | MAPT (0.50) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL11055761 | 0.80 | MAPK1 (0.50) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL11391208 | 0.77 | ALDH1A1 (0.47) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL3487466 | 0.76 | HCAR3 (0.51) | ALDH1A1NPSR1MAPK1TSHRMAPT | |
| SCHEMBL3487462 | 0.76 | HCAR3 (0.51) | ALDH1A1NPSR1MAPK1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |