Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682670 | 0.95 | ALDH1A1 (0.43) | GRIN1GRIN2AGRIN2BALDH1A1HTT | |
| SCHEMBL3666780 | 0.81 | MEN1 (0.47) | ALDH1A1MEN1CYP2C9KMT2AOPRM1 | |
| SCHEMBL1944655 | 0.76 | MEN1 (0.45) | GRIN1GRIN2AGRIN2BMEN1CYP2C9 | |
| SCHEMBL15659683 | 0.74 | HDAC4 (0.44) | GRIN1GRIN2AGRIN2BMEN1CYP2C9 | |
| SCHEMBL15656775 | 0.74 | HDAC4 (0.44) | GRIN1GRIN2AGRIN2BMEN1CYP2C9 | |
| SCHEMBL13853045 | 0.72 | OPRM1 (0.41) | ALDH1A1MEN1CYP2C9KMT2AOPRM1 | |
| SCHEMBL11873107 | 0.71 | KMT2A (0.40) | GRIN1GRIN2AGRIN2BALDH1A1HTT | |
| SCHEMBL11489569 | 0.69 | MEN1 (0.50) | ALDH1A1MEN1CYP2C9KMT2AOPRM1 | |
| SCHEMBL13330626 | 0.69 | GRIN1 (0.49) | GRIN1GRIN2AGRIN2BALDH1A1HTT | |
| SCHEMBL7945256 | 0.69 | GRIN1 (0.41) | GRIN1GRIN2AGRIN2BALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118697-A | Acyl-coenzyme A: cholesterol acyltransferase inhibitors for reducing blood cholesterol levels | WARNER-LAMBERT COMPANY (US) | 1992-06-02 | — | — | US | disclosed |