Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685457 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9683310 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9684112 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9684119 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9684240 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9683304 | 0.87 | MEN1 (0.76) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL9684970 | 0.86 | MEN1 (0.74) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL9684962 | 0.86 | MEN1 (0.74) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL7267140 | 0.83 | ALDH1A1 (0.74) | MEN1ALDH1A1KMT2AADRB3ADRB2 | |
| SCHEMBL9683318 | 0.83 | ALDH1A1 (0.58) | MEN1ALDH1A1KMT2AADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |