Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 9/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683315 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HPGDF2PRSS1TMPRSS15 | |
| SCHEMBL10130610 | 0.87 | ALDH1A1 (0.59) | ALDH1A1HPGDF2PRSS1TMPRSS15 | |
| SCHEMBL10731118 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HPGDPRSS1TMPRSS15HTT | |
| SCHEMBL10731111 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HPGDPRSS1TMPRSS15HTT | |
| SCHEMBL9684157 | 0.83 | F2 (0.43) | ALDH1A1HPGDF2PRSS1TMPRSS15 | |
| SCHEMBL9685380 | 0.83 | F2 (0.43) | ALDH1A1HPGDF2PRSS1TMPRSS15 | |
| SCHEMBL27329284 | 0.82 | F2 (0.46) | ALDH1A1HPGDF2PRSS1TMPRSS15 | |
| SCHEMBL29169158 | 0.81 | NPSR1 (0.46) | ALDH1A1HPGDPRSS1TMPRSS15 | |
| SCHEMBL10725715 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HPGDPRSS1TMPRSS15HTT | |
| SCHEMBL7436196 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HPGDPRSS1TMPRSS15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |