Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684157 | 1.00 | F2 (0.43) | F2POLBTDP1ALDH1A1LMNA | |
| SCHEMBL10728124 | 0.87 | ALDH1A1 (0.53) | POLBTDP1ALDH1A1LMNAPRNP | |
| SCHEMBL9684860 | 0.87 | ALDH1A1 (0.53) | POLBTDP1ALDH1A1LMNAPRNP | |
| SCHEMBL9684856 | 0.87 | ALDH1A1 (0.53) | POLBTDP1ALDH1A1LMNAPRNP | |
| SCHEMBL9683315 | 0.83 | ALDH1A1 (0.46) | F2ALDH1A1HPGDPLAUPRSS1 | |
| SCHEMBL9683316 | 0.83 | ALDH1A1 (0.46) | F2ALDH1A1HPGDPLAUPRSS1 | |
| SCHEMBL10725526 | 0.83 | MRGPRX4 (0.44) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL10725537 | 0.83 | MRGPRX4 (0.44) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL10725518 | 0.83 | MRGPRX4 (0.44) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL9685368 | 0.79 | ALDH1A1 (0.40) | POLBTDP1ALDH1A1LMNAPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |