Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 20/20 | 0.77 |
| ▸ | CA1 | P00915 | 13/20 | 0.77 |
| ▸ | CA12 | O43570 | 8/20 | 0.77 |
| ▸ | CA9 | Q16790 | 6/20 | 0.77 |
| ▸ | CA4 | P22748 | 6/20 | 0.77 |
| ▸ | CA6 | P23280 | 4/20 | 0.77 |
| ▸ | CA5A | P35218 | 4/20 | 0.77 |
| ▸ | CA7 | P43166 | 4/20 | 0.77 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.77 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15193100 | 0.98 | CA2 (0.74) | CA2CA1CA12CA9CA4 | |
| SCHEMBL142107 | 0.87 | CA2 (1.00) | CA2CA1CA12CA9CA4 | |
| Hydrochloric Acid SCHEMBL2352021 | 0.85 | CA2 (0.96) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1805394 | 0.83 | CA2 (0.69) | CA2CA1CA12CA9CA4 | |
| Hydrochloric Acid SCHEMBL27515376 | 0.83 | CA2 (0.92) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1804527 | 0.82 | CA2 (0.52) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1804384 | 0.82 | CA2 (0.70) | CA2CA1CA12CA9CA4 | |
| SCHEMBL8506132 | 0.82 | CA2 (0.67) | CA2CA1CA12CA9CA4 | |
| SCHEMBL6798039 | 0.82 | CA2 (0.52) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1805395 | 0.82 | CA2 (1.00) | CA2CA1CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| CN-1005711-B | Preparation method of phenoxypropanolamine compounds | 弗·哈夫曼-拉罗彻公司 | 1989-11-08 | — | — | CN | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| CN-85101280-A | Benzene oxygen propanol amine compounds | — | 1987-01-17 | — | — | CN | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0101069-B1 | PHENETHANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-04-23 | — | — | EP | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |
| EP-0101069-A1 | Phenethanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
| EP-0094595-A1 | Aziridine and phenylethanol amine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-11-23 | — | — | EP | disclosed |