Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 14/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681396 | 0.89 | TBXA2R (1.00) | TBXA2RALOX5AP | |
| SCHEMBL9682995 | 0.88 | TBXA2R (0.78) | TBXA2RALOX5APAGTR1AGTR2HDAC3 | |
| SCHEMBL9682982 | 0.88 | TBXA2R (0.83) | TBXA2RALOX5AP | |
| SCHEMBL9683466 | 0.83 | TBXA2R (1.00) | TBXA2R | |
| SCHEMBL9683451 | 0.82 | TBXA2R (0.76) | TBXA2R | |
| SCHEMBL9681926 | 0.80 | TBXA2R (0.87) | TBXA2R | |
| SCHEMBL9700305 | 0.79 | TBXA2R (0.82) | TBXA2R | |
| SCHEMBL9681381 | 0.78 | TBXA2R (0.79) | TBXA2RALOX5AP | |
| SCHEMBL9681409 | 0.77 | TBXA2R (0.66) | TBXA2RALOX5AP | |
| SCHEMBL9682433 | 0.76 | TBXA2R (0.77) | TBXA2RALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |