Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 8/20 | 0.78 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681381 | 0.90 | TBXA2R (0.79) | TBXA2RALOX5AP | |
| SCHEMBL9681409 | 0.89 | TBXA2R (0.66) | TBXA2RALOX5AP | |
| SCHEMBL9683350 | 0.88 | TBXA2R (1.00) | TBXA2RALOX5APAGTR1AGTR2HDAC3 | |
| SCHEMBL9682437 | 0.85 | TBXA2R (0.76) | TBXA2RALOX5APAGTR1AGTR2MEN1 | |
| SCHEMBL9682396 | 0.84 | TBXA2R (0.58) | TBXA2RALOX5AP | |
| SCHEMBL9683508 | 0.81 | TBXA2R (0.62) | TBXA2RALOX5APRAB9A | |
| SCHEMBL9681793 | 0.81 | TBXA2R (0.67) | TBXA2RAGTR1AGTR2MEN1KMT2A | |
| SCHEMBL9683313 | 0.79 | TBXA2R (0.64) | TBXA2RALOX5APAGTR1AGTR2MEN1 | |
| SCHEMBL9681443 | 0.79 | TBXA2R (0.61) | TBXA2RALOX5APAGTR1AGTR2MAPK1 | |
| SCHEMBL9683131 | 0.78 | TBXA2R (0.76) | TBXA2RRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |