Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 5/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951084 | 0.67 | GRM2 (0.46) | TRAP1HSP90B1CHRM5GRM2AKR1B1 | |
| SCHEMBL1641009 | 0.65 | KDM4E (0.67) | OPRM1 | |
| SCHEMBL1424192 | 0.65 | BDKRB1 (0.50) | TRAP1HSP90B1CHRM5GRM2AKR1B1 | |
| SCHEMBL1427498 | 0.64 | KDM4E (0.70) | OPRM1 | |
| SCHEMBL28954747 | 0.63 | HDAC1 (0.47) | GRM2AKR1B1OPRM1P2RX7 | |
| SCHEMBL14892161 | 0.63 | PYCR1 (0.46) | TRAP1HSP90B1CHRM5AKR1B1 | |
| SCHEMBL2095254 | 0.63 | PYCR1 (0.46) | TRAP1HSP90B1CHRM5HSP90AA1HSP90AB1 | |
| SCHEMBL7701 | 0.63 | PYCR1 (0.46) | TRAP1HSP90B1CHRM5HSP90AA1HSP90AB1 | |
| SCHEMBL30789000 | 0.63 | PYCR1 (0.46) | TRAP1HSP90B1CHRM5HSP90AA1HSP90AB1 | |
| SCHEMBL24215709 | 0.63 | KDM4E (0.42) | TRAP1HSP90B1CHRM5OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |