SCHEMBL9683664

SCHEMBL9683664

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(Oc2ccccc2)c(Cl)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
STK39 Q9UEW8 1/20 0.52
NPC1 O15118 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
USP2 O75604 1/20 0.45
MAPT P10636 1/20 0.45
ALOX15 P16050 1/20 0.45
TLR8 Q9NR97 4/20 0.45
TLR7 Q9NYK1 3/20 0.45
PYGL P06737 1/20 0.44
RAB9A P51151 2/20 0.44
GCGR P47871 1/20 0.44
ATM Q13315 1/20 0.43
PNLIP P16233 1/20 0.42
PPIA P62937 1/20 0.42
LMNA P02545 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4152345 0.92 MEN1 (0.51) MEN1KMT2ASTK39NPC1KDM4E
SCHEMBL10604227 0.89 MEN1 (0.51) MEN1KMT2ASTK39NPC1KDM4E
SCHEMBL11133448 0.88 STK39 (0.55) STK39NPC1MAPTTLR8PYGL
SCHEMBL8662609 0.88 TLR8 (0.54) MEN1KMT2ANPC1KDM4EALDH1A1
SCHEMBL10630019 0.88 TDP1 (0.54) MEN1KMT2ANPC1KDM4EALDH1A1
SCHEMBL8666499 0.87 KDM4E (0.52) MEN1KMT2ASTK39NPC1KDM4E
SCHEMBL8657706 0.87 MEN1 (0.49) MEN1KMT2ASTK39NPC1KDM4E
SCHEMBL8657651 0.87 GCGR (0.47) MEN1KMT2ASTK39NPC1KDM4E
SCHEMBL9135345 0.86 MAPT (0.47) MEN1KMT2ANPC1KDM4EALDH1A1
SCHEMBL10919264 0.85 GCGR (0.45) MEN1KMT2ASTK39NPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166179-A Insecticides LANGE ARNO (DE) 1992-11-24 US disclosed