Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684151 | 1.00 | POLB (0.54) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL7694702 | 0.92 | ALDH1A1 (0.64) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL7694701 | 0.92 | ALDH1A1 (0.64) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL9685331 | 0.89 | ALDH1A1 (0.57) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL9685334 | 0.89 | ALDH1A1 (0.57) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL8758147 | 0.86 | BCHE (0.71) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL27299325 | 0.84 | ALDH1A1 (0.71) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL7689571 | 0.81 | ALDH1A1 (0.63) | POLBALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL759782 | 0.79 | ALDH1A1 (0.67) | POLBALDH1A1MAPTCYP2D6NPSR1 | |
| SCHEMBL10346703 | 0.79 | ALDH1A1 (0.63) | POLBALDH1A1MAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |