Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684273 | 1.00 | KDM4E (0.46) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9787234 | 0.85 | MAPK1 (0.52) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9787231 | 0.85 | MAPK1 (0.52) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9685147 | 0.83 | ACKR3 (0.46) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9685156 | 0.83 | ACKR3 (0.46) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9684236 | 0.81 | MEN1 (0.48) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9684239 | 0.81 | MEN1 (0.48) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL6931910 | 0.78 | MAPK1 (0.69) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9684101 | 0.78 | KDM4E (0.47) | KDM4EMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9684113 | 0.78 | KDM4E (0.47) | KDM4EMAPK1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |