Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685156 | 1.00 | ACKR3 (0.46) | ACKR3POLBNPSR1KDM4EMAPK1 | |
| SCHEMBL9685400 | 0.86 | ADRB1 (0.47) | CYP1A2CYP2D6RAB9ANPC1USP2 | |
| SCHEMBL9684113 | 0.85 | KDM4E (0.47) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9684101 | 0.85 | KDM4E (0.47) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9684278 | 0.83 | KDM4E (0.46) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9684273 | 0.83 | KDM4E (0.46) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9787231 | 0.81 | MAPK1 (0.52) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9787234 | 0.81 | MAPK1 (0.52) | POLBNPSR1KDM4EMAPK1TDP1 | |
| SCHEMBL9684886 | 0.77 | ALDH1A1 (0.47) | POLBNPSR1MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL9684893 | 0.77 | ALDH1A1 (0.47) | POLBNPSR1MAPK1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |