SCHEMBL9684612

SCHEMBL9684612

Clc1ccc(Oc2ccc[c]n2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
HAO1 Q9UJM8 2/20 0.43
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
MAPK1 P28482 1/20 0.35
TSHR P16473 1/20 0.35
LTA4H P09960 3/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.34
GAA P10253 1/20 0.34
SCN9A Q15858 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2C9 P11712 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1451793 0.82 LTA4H (0.44) HTTL3MBTL1HAO1MEN1KMT2A
SCHEMBL6544233 0.81 MEN1 (0.46) HTTMEN1KMT2AMAPK1LTA4H
SCHEMBL9687059 0.81 MAPT (0.39) MEN1KMT2AMAOAMAOBTSHR
SCHEMBL9685498 0.81 MEN1 (0.52) HTTMEN1KMT2ATSHRRAB9A
SCHEMBL9480616 0.81 LTA4H (0.45) HTTL3MBTL1HAO1MEN1KMT2A
SCHEMBL9686329 0.81 MEN1 (0.44) HTTL3MBTL1MEN1KMT2AGAA
SCHEMBL443386 0.81 ALDH1A1 (0.46) L3MBTL1MEN1KMT2AMAOAMAOB
SCHEMBL9685341 0.81 CYP1A2 (0.48) CYP1A2CYP2C9CYP2C19
SCHEMBL9479749 0.77 LTA4H (0.50) KMT2ATSHRLTA4HRAB9ASMN1; SMN2
SCHEMBL2752491 0.77 MAP4K4 (0.43) KMT2ASCN9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1032005-C Novel silane derivatives, formulations containing them and their use as pesticides HOECHST AG (DE) 1996-06-12 CN disclosed
CN-1091425-A Heterocyclic neophenan analogs, process for their preparation and their use as pesticides HOECHST AG (DE) 1994-08-31 CN disclosed
EP-0288810-B1 HETEROCYCLIC NEOPHANE ANALOGS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1992-12-02 EP disclosed
US-5116826-A SILAZANEOPHYL SULFIDES, AND THEIR USE AS PESTICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1992-05-26 US disclosed
CN-1050878-A Novel silane derivs contains the preparation of this derivative and as the application of agricultural chemicals HOECHST AG (DE) 1991-04-24 CN disclosed
US-5002957-A Insecticides, acaricides, nematocides HOECHST AKTIENGESELLSCHAFT (DE) 1991-03-26 US disclosed
US-4990621-A Insecticides, miticides and nematocides; 3-(3-fluoro-4-phenoxyphenyl, 3-(5-fluoro-3-phenoxypyrid-2-yl) or 3-(3-methyl-4-phenyl prop-1-ene HOECHST AKTIENGESELLSCHAFT (DE) 1991-02-05 US disclosed
US-4966902-A INSECTICIDES, MITICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-30 US disclosed
EP-0249015-B1 SILANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AGENTS CONTAINING THEM, AND THEIR USE AS PESTICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1990-06-27 EP disclosed
EP-0224024-B1 SILANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AGENTS CONTAINING THEM AND THEIR USE AS PESTICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1990-06-20 EP disclosed
EP-0336199-A1 Azaneophyl and silazaneophyl sulfides, process for their preparation, agents containing them, and their use as pesticides HOECHST AKTIENGESELLSCHAFT (DE) 1989-10-11 EP disclosed
US-4864027-A INSECTICIDES, NEMATOCIDES, MITICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1989-09-05 US disclosed
EP-0288810-A1 Heterocyclic neophane analogs, processes for their preparation and their use as pesticides HOECHST AKTIENGESELLSCHAFT (DE) 1988-11-02 EP disclosed
US-4775664-A INSECTICIDES, MITICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1988-10-04 US disclosed
EP-0249015-A1 Silane derivatives, process for their preparation, agents containing them, and their use as pesticides HOECHST AKTIENGESELLSCHAFT (DE) 1987-12-16 EP disclosed
EP-0224024-A1 Silane derivatives, process for their preparation, agents containing them and their use as pesticides HOECHST AKTIENGESELLSCHAFT (DE) 1987-06-03 EP disclosed