Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10395363 | 0.86 | LMNA (0.40) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL10747242 | 0.86 | LMNA (0.37) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL9685810 | 0.84 | LMNA (0.39) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL9684714 | 0.83 | LMNA (0.38) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL9686200 | 0.81 | LMNA (0.36) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL9686764 | 0.79 | ALDH1A1 (0.41) | LMNAPARP1HTTPARP2ALDH1A1 | |
| SCHEMBL9686442 | 0.79 | HTT (0.38) | LMNAPARP1HTTPARP2CHRNE | |
| SCHEMBL9684592 | 0.78 | PARP1 (0.42) | LMNAPARP1HTTPARP2ALDH1A1 | |
| SCHEMBL2657022 | 0.77 | LMNA (0.41) | LMNAPARP1HTTPARP2ALDH1A1 | |
| SCHEMBL2655615 | 0.77 | LMNA (0.41) | LMNAPARP1HTTPARP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245053-B1 | HETEROCYCLIC FUSED TRICYCLIC COMPOUNDS | ICI AMERICAS INC. (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0245053-A1 | Heterocyclic fused tricyclic compounds | ICI AMERICAS INC. (US) | 1987-11-11 | — | — | EP | disclosed |