Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423302 | 0.85 | MAPT (0.62) | ALDH1A1MAPTLMNAPTPRCL3MBTL1 | |
| SCHEMBL9684473 | 0.80 | MAPT (0.54) | ALDH1A1MAPTLMNAPTPRCKMT2A | |
| SCHEMBL7829487 | 0.78 | KEAP1 (0.73) | GRK6KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL9683960 | 0.77 | GRK6 (0.49) | GRK6KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL9316584 | 0.77 | KEAP1 (0.57) | GRK6KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL11077569 | 0.76 | MCL1 (0.58) | ALDH1A1MAPTLMNAPTPRCL3MBTL1 | |
| SCHEMBL9270325 | 0.75 | PTPRC (0.57) | ALDH1A1MAPTLMNAPTPRCL3MBTL1 | |
| SCHEMBL7121384 | 0.74 | KEAP1 (0.86) | GRK6KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL8954279 | 0.73 | PTPRC (0.50) | ALDH1A1MAPTLMNAPTPRCL3MBTL1 | |
| SCHEMBL27637350 | 0.73 | KEAP1 (0.83) | GRK6KEAP1NFE2L2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5144028-A | Antibiotics | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0469844-A1 | 2-(9-fluorenonyl)-carbapenem | MERCK & CO. INC. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5025007-A | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |