Sugi Predict

Sugi Predict / Compounds / SCHEMBL968490

SCHEMBL968490

SCHEMBL968490

Nc1ncnc2sccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DYRK1A Q13627 2/20 1.00
▸ CHEK1 O14757 1/20 1.00
▸ AURKA O14965 1/20 1.00
▸ DAPK3 O43293 1/20 1.00
▸ JAK2 O60674 1/20 1.00
▸ MAP4K4 O95819 1/20 1.00
▸ ABL1 P00519 1/20 1.00
▸ NTRK1 P04629 1/20 1.00
▸ LCK P06239 1/20 1.00
▸ FYN P06241 1/20 1.00
▸ CSF1R P07333 1/20 1.00
▸ RET P07949 1/20 1.00
▸ IGF1R P08069 1/20 1.00
▸ MET P08581 1/20 1.00
▸ PDGFRB P09619 1/20 1.00
▸ PIM1 P11309 1/20 1.00
▸ FGFR1 P11362 1/20 1.00
▸ PRKACA P17612 1/20 1.00
▸ LTK P29376 1/20 1.00
▸ KDR P35968 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2843606 0.76 CHEK1 (0.61) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL9704 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL30958678 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL8018832 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL1192489 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL12559905 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL22412847 0.74 CHEK1 (0.59) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL11488262 0.74 CHEK1 (0.58) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL966279 0.71 DYRK1A (0.55) DYRK1ACHEK1AURKADAPK3JAK2
SCHEMBL27706145 0.71 DYRK1A (0.55) DYRK1ACHEK1AURKADAPK3JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS ITALFARMACO SPA (IT) 2023-09-14 — — US claimed
US-9133209-B2 Insecticidal 4-amino-thieno[2,3-D]-pyrimidine compounds and methods of their use MERIAL, INC. (US) 2015-09-15 — — US claimed
EP-2459569-B1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE MERIAL INC (US) 2015-07-22 — — EP claimed
CN-1823071-B Thienopyrimidine derivatives as potassium channel inhibitors XENTION DISCOVERY LTD 2012-12-19 — — CN claimed
US-20120252667-A1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE MERIAL, INC. 2012-10-04 — — US claimed
CN-102596968-A Insecticidal 4-amino-thieno[2,3-d]-pyrimidine compounds and methods of their use MERIAL LTD 2012-07-18 — — CN claimed
EP-2459569-A1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE Merial Limited (US) 2012-06-06 — — EP claimed
CN-101448840-B Tetrahydropyridothienopyrimidine compounds and methods of use thereof BAYER SCHERING PHARMA AG (DE) 2011-12-14 — — CN claimed
WO-2011014660-A1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE MERIAL LIMITED (US) 2011-02-03 — — WO claimed
CN-101448840-A Tetrahydropyridothienopyrimidine compounds and methods of use thereof BAYER PHARMACEUTICALS CORP (DE) 2009-06-03 — — CN claimed
CN-101100472-A 4-amino-5,6-substituted thiopheno [2,3-D] pyrimidines compound and its uses BAYER PHARMACEUTICALS CORP (US) 2008-01-09 — — CN claimed
CN-101048412-A Piperidinylamino-thieno [2, 3-D ] pyrimidine compounds EPIX DELAWARE INC (US) 2007-10-03 — — CN claimed
EP-1797099-A1 PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS Epix Delaware, Inc. (US) 2007-06-20 — — EP claimed
CN-1823071-A Thienopyrimidine derivatives as potassium channel inhibitors XENTION DISCOVERY LTD (GB) 2006-08-23 — — CN claimed
WO-2006034511-A1 PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS EPIX DELAWARE, INC. (US) 2006-03-30 — — WO claimed
CN-1522258-A Novel 4-amino-5, 6-substituted thieno [2, 3-D ] pyrimidine compounds — 2004-08-18 — — CN claimed
EP-0452002-A2 Thienopyrimidine derivatives DOWELANCO (US) 1991-10-16 — — EP claimed
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF CASE WESTERN RESERVE UNIV (US) 2026-05-14 — — US disclosed
US-4196207-A Process for controlling eradicating or preventing infestations of animals by Ixodid ticks ICI AUSTRALIA LIMITED 1980-04-01 — — US disclosed
US-4146716-A PLANT GROWTH REGULATORS, FUNGICIDES, BACTERICIDES, VIRICIDES, INSECTICIDES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-03-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF BAX, BCL2, BAK1 DYRK1A 4064/4885CHEK1 326/4885AURKA 3878/4885
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS HDAC6, HDAC1, HDAC3 DYRK1A 2513/4885CHEK1 1918/4885AURKA 125/4885
US-20120252667-A1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE P2RX2, P2RX5, P2RX1 DYRK1A 676/4885CHEK1 1998/4885AURKA 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.