Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684812 | 0.89 | ALDH1A1 (0.53) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL13649357 | 0.86 | MAPT (0.59) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL28669771 | 0.85 | MAPT (0.50) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL17702874 | 0.84 | MAPT (0.47) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL5820368 | 0.83 | MAPT (0.58) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL13649352 | 0.82 | MAPT (0.51) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL28288758 | 0.80 | MAPT (0.56) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL30005823 | 0.80 | MAPT (0.56) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL4446630 | 0.80 | MAPT (0.56) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL11421782 | 0.79 | MAPT (0.55) | MAPTALDH1A1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145975-A | Parasiticides | THE ROCKEFELLER UNIVERSITY (US) | 1992-09-08 | — | — | US | disclosed |
| US-4942170-A | PARASITICIDES, ANTIPROTOZOA AGENTS | THE ROCKEFELLER UNIVERSITY (US) | 1990-07-17 | — | — | US | disclosed |
| EP-0355279-A2 | Use of nitrogen-containing compounds as antiparasitics, and compositions containing them | DRUG & VACCINE DEVELOPMENT CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |