Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.63 |
| ▸ | LMNA | P02545 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP5 | P51878 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898023 | 0.81 | HTT (0.64) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9685116 | 0.80 | HTT (0.63) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9685234 | 0.79 | HTT (0.62) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9684472 | 0.79 | ALDH1A1 (0.46) | LMNAALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL8808754 | 0.78 | HTT (0.64) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9686720 | 0.78 | HTT (0.61) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9685255 | 0.78 | HTT (1.00) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9686172 | 0.78 | LMNA (0.60) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8808001 | 0.76 | HTT (0.67) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9686619 | 0.76 | LMNA (0.58) | HTTLMNAALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61243082-A | — | — | None | — | — | JP | disclosed |
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| JP-S61243082-A | 2-PIPERAZINOPYRIMIDINE DERIVATIVE | MITSUI PETROCHEM IND LTD | 1986-10-29 | — | — | JP | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |