Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Velnacrine SCHEMBL194467 | 0.82 | CYP1A2 (1.00) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL9875466 | 0.77 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL9654428 | 0.77 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL9651915 | 0.77 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL10846147 | 0.76 | ACHE (0.69) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL10642848 | 0.76 | ACHE (0.45) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL10843037 | 0.75 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL9874959 | 0.75 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL10845949 | 0.75 | ACHE (0.67) | ACHECYP1A2CYP2C9TSHRALDH1A1 | |
| Velnacrine SCHEMBL637476 | 0.74 | TSHR (0.83) | ACHECYP1A2CYP2C9TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | claimed |
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |