Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686141 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL9686615 | 0.85 | ADRA1A (0.49) | ADRA2CADRA1AADRA1BKCNH2 | |
| SCHEMBL9686198 | 0.85 | TSHR (0.40) | — | |
| SCHEMBL11869688 | 0.76 | KDM4E (0.78) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL31187488 | 0.76 | KDM4E (0.82) | ADRA1AADRA1B | |
| SCHEMBL31151021 | 0.75 | EHMT2 (0.69) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5137299 | 0.74 | KDM4E (0.76) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL29393496 | 0.74 | POLB (0.80) | ADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9686209 | 0.74 | POLB (0.56) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL30555731 | 0.74 | EHMT2 (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |