Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.49 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6347645 | 0.92 | SMN1; SMN2 (0.54) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| Bicarbonate SCHEMBL1720129 | 0.91 | NPC1 (0.48) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL11282272 | 0.90 | SLC18A3 (0.51) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL43080 | 0.89 | SLC18A3 (0.56) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| Glycolic Acid SCHEMBL2763521 | 0.87 | SMN1; SMN2 (0.50) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL8025878 | 0.87 | LMNA (0.59) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL346325 | 0.87 | LMNA (0.59) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL28722738 | 0.87 | LMNA (0.59) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL2537599 | 0.84 | SLC18A3 (0.52) | SLC18A3SMN1; SMN2TP53ALDH1A1LMNA | |
| Bicarbonate SCHEMBL9512998 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485929-A1 | Substituted azoles, process for their preparation and their application | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-20 | — | — | EP | disclosed |